The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …

Osteoporosis is a skeletal disorder characterized by bone loss, which results in architectural
deterioration of the skeleton, compromised bone strength and an increased risk of fragility …

Osteosarcoma (OS) therapy faces many challenges, especially the poor survival rate once
metastasis occurs. Therefore, it is crucial to explore new OS treatment strategies that can …

Cancer development depends on the aberrant activation of signal transduction pathways
that control cell growth and survival and play important roles in normal embryonic …

Osteosarcoma is the most common primary malignant bone tumor in children and young
adults. The standard-of-care curative treatment for osteosarcoma utilizes doxorubicin …

Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …

Osteosarcoma is the most common nonhematologic malignancy of bone in children and
adults. The peak incidence occurs in the second decade of life, with a smaller peak after age …

Introduction 3. Stem cells and mesenchymal stem cells 4. Mesenchymal stem cell lineages
4.1. Myogenic lineage 4.2. Adipogenic lineage 4.3. Chondrogenic lineage 4.4. Osteogenic …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and
expansion and forms the basis for novel anabolic therapeutic strategies being developed for …