The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

Synucleinopathies are a group of neurodegenerative disorders caused by the accumulation
of toxic species of α-synuclein. The common clinical features are chronic progressive …

Monocytes/macrophages are innate immune cells that play a crucial role in the resolution of
inflammation. In the presence of the Th2 cytokines interleukin-4 (IL-4) and interleukin-13 (IL …

Positron emission tomography (PET) imaging of monoamine oxidases (MAO-A:[11C]
harmine,[11C] clorgyline, and [11C] befloxatone; MAO-B:[11C] deprenyl-D2) has been …

The biological roles of mitochondrial-produced reactive oxygen species continue to receive
intensive investigation since one of the products (H2O2) has important cellular signaling …

It would not be practical to attempt to deal with all the advances that have informed our
understanding of the behavior and functions of this enzyme over the past 90 years. This …

Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of
biogenic amines into their corresponding aldehydes and ketones through oxidative …

Major depressive disorder (MDD) is the leading cause of disability worldwide and is
associated with high rates of suicide and medical comorbidities. Current antidepressant …

Neuroinflammation is an adaptive response of the central nervous system to diverse
potentially injurious stimuli, which is closely associated with neurodegeneration and …

During embryonic development, cardiomyocytes undergo differentiation and maturation,
processes that are tightly regulated by tissue-specific signaling cascades. Although redox …