The primary cilium is an antenna-like, immotile organelle present on most types of
mammalian cells, which interprets extracellular signals that regulate growth and …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

Membrane association with mother centriole (M-centriole) distal appendages is critical for
ciliogenesis initiation. How the Rab GTPase Rab11–Rab8 cascade functions in early ciliary …

The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …

Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal
end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia …

Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella.
These organelles play essential roles in motility and signaling on the surface of cells. Cilia …

Centrioles are vital cellular structures that form centrosomes and cilia. The formation and
function of cilia depends on a set of centriole's distal appendages. In this study, we use …

Obtaining the high-resolution structures of proteins and their complexes is a crucial aspect of
understanding the mechanisms of life. Experimental structure determination methods are …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease without any
effective treatment. Protein TDP-43 is a pathological hallmark of ALS in both sporadic and …