Sepsis is the life-threatening organ dysfunction caused by a dysregulated host response to
infection and is the leading cause of death in intensive care units. Cardiac dysfunction …

It has long been observed that heart failure (HF) is associated with measures of systemic
inflammation. In recent years, there have been significant advancements in our …

Abstract Purpose of Review With the intention to summarize the currently available evidence
on the pathophysiological relevance of inflammation in heart failure, this review addresses …

Atrial fibrillation (AF) is the most common cardiac arrhythmia. However, the development of
preventative therapies for AF has been disappointing. The infiltration of immune cells and …

IL-1β production is critically regulated by cytosolic molecular complexes, termed
inflammasomes. Different inflammasome complexes have been described to date. While all …

Excessive feeding is associated with an increase in the incidence of chronic metabolic
diseases, such as obesity, insulin resistance, and type 2 diabetes. Metabolic disturbance …

Cardiovascular diseases (CVDs) are one of the leading causes of the most considerable
mortality globally, and it has been tried to find the molecular mechanisms and design new …

ZBP1 is widely recognized as a mediator of cell death for its role in initiating necroptotic,
apoptotic, and pyroptotic cell death pathways in response to diverse pathogenic infection …

Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …

A decrease in the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) increases
the amount of low-density lipoprotein (LDL) receptors on liver cells and, therefore, LDL …