Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic
alterations. Often, these changes underlie cancer development, progression, and drug …

Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Background Papillary renal-cell carcinoma, which accounts for 15 to 20% of renal-cell
carcinomas, is a heterogeneous disease that consists of various types of renal cancer …

Abstract CellMiner Cross-Database (CellMinerCDB, discover. nci. nih. gov/cellminercdb)
allows integration and analysis of molecular and pharmacological data within and across …

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from
resting tissues. More recently understood is that this metabolic phenotype is not unique to …

Tumor-derived cell lines have served as vital models to advance our understanding of
oncogene function and therapeutic responses. Although substantial effort has been made to …

High-throughput and high-content databases are increasingly important resources in
molecular medicine, systems biology, and pharmacology. However, the information usually …

Background Apoptosis and other forms of cell death have been intensively investigated in
the past years to explain the mode of action of synthetic anticancer drugs and natural …

Feature selection is an important problem for pattern classification systems. We study how to
select good features according to the maximal statistical dependency criterion based on …

Data analysis plays an indispensable role for understanding various phenomena. Cluster
analysis, primitive exploration with little or no prior knowledge, consists of research …