The nucleolus is a prominent subnuclear compartment, where ribosome biosynthesis takes
place. Recently, the nucleolus has gained attention for its novel role in the regulation of …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

Besides the canonical function in ribosome biogenesis, there have been significant recent
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …

Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in
human cells. The canonical function of box C/D and box H/ACA snoRNAs is …

Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in
yeast have established some of the biological principles of ribosome biogenesis, many of …

More than half of the human genome consists of repetitive sequences, with the ribosomal
DNA (rDNA) representing two of the largest repeats. Repetitive rDNA sequences may form a …

The nucleolus is the subnuclear membrane-less organelle where rRNA is transcribed and
processed and ribosomal assembly occurs. During the last 20 years, however, the nucleolus …

Drug-induced cardiotoxicity (DICT) is a major concern in drug development, accounting for
10–14% of postmarket withdrawals. In this study, we explored the capabilities of chemical …

Aims The ageing heart naturally incurs a progressive decline in function and perfusion that
available treatments cannot halt. However, some exceptional individuals maintain good …