Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced
response to insulin of several tissues, including myocardial and skeletal muscle. IRES is …

G-protein-coupled receptor kinase 2 (GRK2) is a G-protein-coupled receptor kinase that is
ubiquitously expressed in many tissues and regulates various intracellular mechanisms. The …

Aims The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are
unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by …

Despite the availability of several therapies for the management of blood glucose in diabetic
patients, most of the treatments do not show benefits on diabetic cardiomyopathy, while …

Cardiovascular disease and heart failure (HF) still collect the largest toll of death in western
societies and all over the world. A growing number of molecular mechanisms represent …

G protein-coupled receptor kinase 2 (GRK2), as a vital Ser/Thr kinase, is an important
regulatory protein in the inflammatory immune response (IIR) by maintaining the balance …

GRK5 is a multifunctional protein that is able to move within the cell in response to various
stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane …

Angiotensin II (AII) as well as analog peptides shows antimalarial activity against
Plasmodium gallinaceum and Plasmodium falciparum, but the exact mechanism of action is …

G protein-coupled receptor kinase 2 (GRK2) is a relevant signaling node of the cellular
transduction network, playing major roles in the physiology of various organs/tissues …

The high interest in therapeutic peptides, due to the specificity of their mechanisms of action,
has stimulated the research of new delivery strategies to overcome bioavailability problems …