Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Background: Recently discovered relationships between the gastrointestinal microbiome
and the brain have implications for psychiatric disorders, including major depressive …

Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes
damage to multiple organ systems. Despite decades of research and available murine …

Systemic lupus erythematosus (SLE) is a clinically and genetically heterogeneous
autoimmune disease. The etiology of lupus and the contribution of genetic, environmental …

Monogenic lupus is a form of systemic lupus erythematosus (SLE) that occurs in patients
with a single gene defect. This rare variant of lupus generally presents with early onset …

Systemic lupus erythematosus is the prototypical systemic autoimmune disease, as it is
characterized both by protean multi-organ system manifestations and by the uniform …

Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive
heterogeneity in disease presentation between patients, which is likely due to an underlying …

Exome sequencing has been commonly used to characterize rare diseases by selecting
multiplex families or singletons with an extreme phenotype (EP) and searching for rare …

C1q/TNF-related protein 4 (CTRP4) is generally thought to be released extracellularly and
plays a critical role in energy metabolism and protecting against sepsis. However, its …

Systemic lupus erythematosus (SLE, OMIM 152700) is a systemic autoimmune disease with
a complex etiology. The mode of inheritance of the genetic risk beyond familial SLE cases is …