Carbohydrate polymer-based bioadhesive formulations and their potentials for the treatment of ocular diseases: a review

X Tang, J Liu, R Yan, Q Peng - International Journal of Biological …, 2023 - Elsevier
Eyes are directly exposed to the outer environment and susceptible to infections, leading to
various ocular disorders. Local medication is preferred to treat eye diseases due to its …

Insight into the effect of biomaterials on osteogenic differentiation of mesenchymal stem cells: a review from a mitochondrial perspective

Z Feng, M Jin, J Liang, J Kang, H Yang, S Guo, X Sun - Acta Biomaterialia, 2023 - Elsevier
Bone damage may be triggered by a variety of factors, and the damaged area often requires
a bone graft. Bone tissue engineering can serve as an alternative strategy for repairing large …

Optimization of an injectable hydrogel depot system for the controlled release of retinal-targeted hybrid nanoparticles

I Ottonelli, A Bighinati, E Adani, F Loll, R Caraffi… - Pharmaceutics, 2022 - mdpi.com
A drawback in the development of treatments that can reach the retina is the presence of
barriers in the eye that restrain compounds from reaching the target. Intravitreal injections …

Recent advances of ocular drug delivery systems: prominence of ocular implants for chronic eye diseases

M Mostafa, A Al Fatease, RG Alany, H Abdelkader - Pharmaceutics, 2023 - mdpi.com
Chronic ocular diseases can seriously impact the eyes and could potentially result in
blindness or serious vision loss. According to the most recent data from the WHO, there are …

The nano-revolution in the diagnosis and treatment of endometriosis

C Volpini, N Bloise, M Dominoni, F Barra, VG Vellone… - Nanoscale, 2023 - pubs.rsc.org
Endometriosis is a painful gynecological disease with a high prevalence, affecting millions
of women worldwide. Innovative, non-invasive treatments, and new patient follow-up …

Chitosan interaction with stomach mucin layer to enhances gastric retention and mucoadhesive properties

K Ahmad, Y Zhang, P Chen, X Yang, H Hou - Carbohydrate Polymers, 2024 - Elsevier
The interaction between mucoadhesive materials and mucin layers is of significant interest
in the development of drug delivery systems and biomedical applications for effective …

Hydrogels in ophthalmology: Novel strategies for overcoming therapeutic challenges

KY Wu, D Akbar, M Giunta, A Kalevar, SD Tran - Materials, 2023 - mdpi.com
The human eye's intricate anatomical and physiological design necessitates tailored
approaches for managing ocular diseases. Recent advancements in ophthalmology …

Injectable Dendrimer Hydrogel Delivers Melphalan in Both Conjugated and Free Forms for Retinoblastoma

RC Cooper, J Wang, H Yang - Biomacromolecules, 2024 - ACS Publications
We report the successful synthesis of an injectable dendrimer hydrogel (DH) carrying
melphalan, a clinical drug for retinoblastoma treatment, in both conjugated and free forms …

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

X Hu, H Wu, X Yong, Y Wang, S Yang, D Fan… - MedComm, 2023 - Wiley Online Library
The endometrium is a unique human tissue with an extraordinary ability to undergo a
hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and …

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

A Hoseinzadeh, H Ghoddusi Johari… - European Journal of …, 2022 - Springer
Angiogenesis is a vital biological process involving blood vessels forming from pre-existing
vascular systems. This process contributes to various physiological activities, including …