C1 inhibitor deficiency: consensus document
MM Gompels, RJ Lock, M Abinun… - Clinical & …, 2005 - academic.oup.com
We present a consensus document on the diagnosis and management of C1 inhibitor
deficiency, a syndrome characterized clinically by recurrent episodes of angio-oedema. In …
deficiency, a syndrome characterized clinically by recurrent episodes of angio-oedema. In …
Glycosylation and the complement system
The human complement pathway is a highly efficient recognition and effector system that is
designed to destroy infectious microbes and damaged host material. Over 30 plasma …
designed to destroy infectious microbes and damaged host material. Over 30 plasma …
Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles
Recombinant Chinese hamster ovary (CHO) cells are able to provide biopharmaceuticals
that are essentially free of human viruses and have N-glycosylation profiles similar, but not …
that are essentially free of human viruses and have N-glycosylation profiles similar, but not …
Engineering of routes to heparin and related polysaccharides
U Bhaskar, E Sterner, AM Hickey, A Onishi… - Applied microbiology …, 2012 - Springer
Anticoagulant heparin has been shown to possess important biological functions that vary
according to its fine structure. Variability within heparin's structure occurs owing to its …
according to its fine structure. Variability within heparin's structure occurs owing to its …
N-and O-glycans of recombinant human C1 inhibitor expressed in the milk of transgenic rabbits
K Koles, PHC van Berkel, FR Pieper, JH Nuijens… - …, 2004 - academic.oup.com
Abstract Human C1 inhibitor (hC1INH) is a therapeutic N, O-glycoprotein with a growing
number of clinical applications, but the current natural supplies are not likely to meet the …
number of clinical applications, but the current natural supplies are not likely to meet the …
C1, MBL–MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation
Complement activation is initiated by the pattern-recognition molecules complement
component C1q, mannose-binding lectin (MBL) and ficolins (H-, L-, M-ficolin), which typically …
component C1q, mannose-binding lectin (MBL) and ficolins (H-, L-, M-ficolin), which typically …
C1-inhibitor: structure, functional diversity and therapeutic development
E Karnaukhova - Current Medicinal Chemistry, 2022 - ingentaconnect.com
Human C1-Inhibitor (C1INH), also known as C1-esterase inhibitor, is an important
multifunctional plasma glycoprotein that is uniquely involved in a regulatory network of …
multifunctional plasma glycoprotein that is uniquely involved in a regulatory network of …
Functional characterization of the recombinant human C1 inhibitor serpin domain: insights into heparin binding
V Rossi, I Bally, S Ancelet, Y Xu… - The Journal of …, 2010 - journals.aai.org
Variants of the human C1 inhibitor serpin domain containing three N-linked carbohydrates at
positions 216, 231, and 330 (C1inhΔ97), a single carbohydrate at position 330 …
positions 216, 231, and 330 (C1inhΔ97), a single carbohydrate at position 330 …
Serpins and the complement system
L Beinrohr, TA Murray-Rust, L Dyksterhuis… - Methods in …, 2011 - Elsevier
Abstract C1-inhibitor (serpin G1) is a 105 kDa inhibitor which functions as a major
antiinflammatory protein in the body. It has its effects via inhibition of the proteases of the …
antiinflammatory protein in the body. It has its effects via inhibition of the proteases of the …
Obstetrical complications and outcome in two families with hereditary angioedema due to mutation in the F12 gene
Backgroud. Hereditary angioedema (HAE) is characterized by recurrent swelling of the skin,
the abdomen (causing severe acute pain), and the airways. A recently discovered type …
the abdomen (causing severe acute pain), and the airways. A recently discovered type …