Continuous flow reactors have earned their place as an important technology in organic
synthesis, receiving increased interest in the past decade. The favorable heat and mass …

Halogenated aryl amines are a widely used chemical feedstock in the pharmaceutical and
agrochemical industries. Achieving a single regioselective product from the para-selective …

An α-chiral pyrrolidine library has been established via a highly diastereoselective
continuous flow protocol under mild conditions. Various functionalized pyrrolidines have …

Rationale 4, 7‐Dichloroquinoline (DCQ) represents a group of synthetic molecules inspired
by natural products with important roles in biological and biomedical areas. This work aimed …

Remifentanil is a modern fentanyl analogue with ultrashort-action granted by an esterase-
labile methyl propanoate chain. Here, we present the development of a continuous flow …

Since the pioneering works of Gilman and Bebb, and Wittig and Furhmann accompanied by
important contributions including Snieckus, directed ortho-metalation reactions (DoM) have …

This chapter addresses recent advances in selective functionalization of the quinazoline
core, which is present in various pharmacologically important molecules and in molecules …

Microwave-mediated N-arylation of 4-chloroquinazolines in THF/H 2 O rapidly and efficiently
afforded a library of novel 6-halo-2-phenyl-substituted 4-anilinoquinazolines. The …