Antibody drug conjugate: the “biological missile” for targeted cancer therapy

Z Fu, S Li, S Han, C Shi, Y Zhang - Signal transduction and targeted …, 2022 - nature.com
Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs)
covalently attached to a cytotoxic drug via a chemical linker. It combines both the …

Site-selective modification strategies in antibody–drug conjugates

SJ Walsh, JD Bargh, FM Dannheim… - Chemical Society …, 2021 - pubs.rsc.org
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …

Antibody–drug conjugates in solid tumors: a look into novel targets

C Criscitiello, S Morganti, G Curigliano - Journal of hematology & oncology, 2021 - Springer
Antibody–drug conjugates (ADCs) are a relatively new class of anticancer agents designed
to merge the selectivity of monoclonal antibodies with cell killing properties of …

Strategies and challenges for the next generation of antibody–drug conjugates

A Beck, L Goetsch, C Dumontet… - Nature reviews Drug …, 2017 - nature.com
Antibody–drug conjugates (ADCs) are one of the fastest growing classes of oncology
therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) …

The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress

JM Sasso, R Tenchov, R Bird, KA Iyer… - Bioconjugate …, 2023 - ACS Publications
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …

Next generation antibody drugs: pursuit of the'high-hanging fruit'

PJ Carter, GA Lazar - Nature Reviews Drug Discovery, 2018 - nature.com
Antibodies are the most rapidly growing drug class and have a major impact on human
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …

Bioconjugation with maleimides: a useful tool for chemical biology

JMJM Ravasco, H Faustino, A Trindade… - … –A European Journal, 2019 - Wiley Online Library
Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic
accessibility, excellent reactivity, and practicability. The second‐generation of clinically …

Antibiotics in the clinical pipeline in October 2019

MS Butler, DL Paterson - The Journal of antibiotics, 2020 - nature.com
The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

Wearable bioelectronics for chronic wound management

C Wang, E Shirzaei Sani, W Gao - Advanced functional …, 2022 - Wiley Online Library
Chronic wounds are a major healthcare issue and can adversely affect the lives of millions
of patients around the world. The current wound management strategies have limited clinical …

[HTML][HTML] A comprehensive review of key factors affecting the efficacy of antibody drug conjugate

A Samantasinghar, NP Sunildutt, F Ahmed… - Biomedicine & …, 2023 - Elsevier
Abstract Antibody Drug Conjugate (ADC) is an emerging technology to overcome the
limitations of chemotherapy by selectively targeting the cancer cells. ADC binds with an …