From the earliest stages of embryonic development, cells of epithelial and mesenchymal
origin contribute to the structure and function of developing organs. However, these …

Nodal-related ligands of the transforming growth factor-beta (TGFβ) superfamily play central
roles in patterning the early embryo during the induction of mesoderm and endoderm and …

Abstract Cripto-1 (CR-1)/Teratocarcinoma-derived growth factor1 (TDGF-1) is a cell surface
glycosylphosphatidylinositol (GPI)-linked glycoprotein that can function either in cis …

Cripto-1 is critical for early embryonic development and, together with its ligand Nodal, has
been found to be associated with the undifferentiated status of mouse and human embryonic …

Postlactational involution is the process following weaning during which the mammary gland
undergoes massive cell death and tissue remodeling as it returns to the pre-pregnant state …

Epithelial-to-mesenchymal transition (EMT) is a critical multistep process that converts
epithelial cells to more motile and invasive mesenchymal cells, contributing to body …

Cripto is a small, GPI-anchored signaling protein that regulates cellular survival,
proliferation, differentiation and migration during normal developmental processes and …

Abstract Purpose: Human Cripto-1 (CR-1), a cell membrane glycosylphosphatidylinositol-
anchored glycoprotein that can also be cleaved from the membrane, is expressed at high …

Several studies have shown that cell fate regulation during embryonic development and
oncogenic transformation share common regulatory mechanisms and signaling pathways …

Aims: Cripto‐1 may be capable of up‐regulating signalling molecules associated with
epithelial‐to‐mesenchymal transition (EMT), an important event characterized by loss of E …