Oncogenic pathways and the electron transport chain: a dangeROS liaison
Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …
Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: a review focusing on mitochondrial respiration and reactive oxygen species
HD Um - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
Although Bcl-2 family proteins were originally identified as key regulators of apoptosis, an
impressive body of evidence has shown that pro-survival members of the Bcl-2 family …
impressive body of evidence has shown that pro-survival members of the Bcl-2 family …
Architecture of human mitochondrial respiratory megacomplex I2III2IV2
R Guo, S Zong, M Wu, J Gu, M Yang - Cell, 2017 - cell.com
The respiratory megacomplex represents the highest-order assembly of respiratory chain
complexes, and it allows mitochondria to respond to energy-requiring conditions. To …
complexes, and it allows mitochondria to respond to energy-requiring conditions. To …
[HTML][HTML] Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA
We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth,
and that tumor formation is associated with acquisition of mtDNA from host cells. This leads …
and that tumor formation is associated with acquisition of mtDNA from host cells. This leads …
[HTML][HTML] Structure of mammalian respiratory supercomplex I1III2IV1
M Wu, J Gu, R Guo, Y Huang, M Yang - Cell, 2016 - cell.com
The mammalian respiratory chain complexes assemble into supercomplexes (SCs) and
reside in the inner mitochondrial membrane to transfer electrons and establish the proton …
reside in the inner mitochondrial membrane to transfer electrons and establish the proton …
The architecture of the mammalian respirasome
J Gu, M Wu, R Guo, K Yan, J Lei, N Gao, M Yang - Nature, 2016 - nature.com
The respiratory chain complexes I, III and IV (CI, CIII and CIV) are present in the bacterial
membrane or the inner mitochondrial membrane and have a role of transferring electrons …
membrane or the inner mitochondrial membrane and have a role of transferring electrons …
Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models
E Howard, BP Hurrell, DG Helou… - Nature …, 2023 - nature.com
Abstract Ca2+ entry via Ca2+ release-activated Ca2+ (CRAC) channels is a predominant
mechanism of intracellular Ca2+ elevation in immune cells. Here we show the …
mechanism of intracellular Ca2+ elevation in immune cells. Here we show the …
Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function
U Martinez-Outschoorn, F Sotgia, MP Lisanti - Seminars in oncology, 2014 - Elsevier
Metabolic synergy or metabolic coupling between glycolytic stromal cells (Warburg effect)
and oxidative cancer cells occurs in human breast cancers and promotes tumor growth. The …
and oxidative cancer cells occurs in human breast cancers and promotes tumor growth. The …
Mitochondrial respiratory chain supercomplexes: from structure to function
S Guan, L Zhao, R Peng - International Journal of Molecular Sciences, 2022 - mdpi.com
Mitochondrial oxidative phospho rylation, the center of cellular metabolism, is pivotal for the
energy production in eukaryotes. Mitochondrial oxidative phosphorylation relies on the …
energy production in eukaryotes. Mitochondrial oxidative phosphorylation relies on the …