Walking exercise is the most effective noninvasive therapy that improves walking ability in
peripheral artery disease (PAD). Biologic mechanisms by which exercise improves walking …

Background The objective of this systematic review is to summarize the available animal
models of ischemic limbs, and to provide an overview of the advantages and disadvantages …

Background: Arterial stiffness and wall shear stress are powerful determinants of
cardiovascular health, and arterial stiffness is associated with increased cardiovascular …

Peripheral arterial disease (PAD) is a progressive atherosclerotic disorder characterized by
blockages of the arteries supplying the lower extremities. Ischemia initiates oxidative …

Objective Previous studies have shown that hydrogen sulfide (H 2 S) exerts potent
proangiogenic properties under in vitro conditions and in rodent models. We sought to …

Background Acute arterial occlusion of the lower extremity is a time-dependent emergency
that requires prompt revascularization. Lower extremity extracorporeal distal …

Peripheral arterial disease is a growing worldwide problem with a wide spectrum of clinical
severity and is projected to consume> $21 billion per year in the United States alone. While …

Background Expression of receptor for advanced glycation end products (RAGE) plays an
important role in diabetic peripheral artery disease. We proposed to show that treatment with …

This work sought to develop a robust and clinically relevant swine model of critical limb
ischemia (CLI) involving the onset of ischemic muscle necrosis. CLI carries about 25–40 …

Currently, there is no large animal model of sustained limb ischemia suitable for testing
novel angiogenic therapeutics for peripheral artery disease (PAD) such as drugs, genes …