Sulfoxide-containing molecules are an important class of compounds in the pharmaceutical
industry and many efforts have been made to develop new and green protocols, targeting …

Self-driving laboratories, in the form of automated experimentation platforms guided by
machine learning algorithms, have emerged as a potential solution to the need for …

Catalytic use of peroxomolybdate for asymmetric transformations has attracted increasing
attention due to its catalytic properties and application in catalysis. Herein, we report chiral …

Modafinil is a synthetic molecule used for the treatment of narcolepsy. Narcolepsy is a
neurological disorder, due to which people experience frequent excessive daytime …

A series of modafinil (1) analogues were synthesized wherein (1) para-halo-substitutents
were added to the aryl rings,(2) the sulfoxide function was removed, and (3) the primary …

2-[(Diphenylmethyl) sulfinyl] acetamide (modafinil,(±)-1) is a unique dopamine uptake
inhibitor that binds the dopamine transporter (DAT) differently than cocaine and may have …

α-Deuterated alcohols have important applications in pharmaceuticals and mechanism
studies. Here, we report a new and practical strategy for the reductive deuteration of ketones …

Blockade of dopamine (DA) reuptake via the dopamine transporter (DAT) is a primary
mechanism identified as underlying the therapeutic actions of (±)‐modafinil (modafinil) and …

Small-and intermediate-conductance Ca 2+-activated K+ channels, K Ca 2.3 and K Ca 3.1,
are involved in cellular signaling processes associated with inflammation and fibrosis. K Ca …

Recent discoveries have improved our understanding of the physiological and pathological
roles of the dopamine transporter (DAT); however, only a few drugs are clinically available …