The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for
understanding the successive somatic genetic changes and consequent clonal expansions …

Background Idiopathic pulmonary fibrosis (IPF) risk has a strong genetic component. Studies
have implicated variations at several loci, including TERT, surfactant genes, and a single …

Background DNA is subject to constant chemical modification and damage, which
eventually results in variable mutation rates throughout the genome. Although detailed …

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They
achieve this through TERT activation or alternative telomere lengthening associated with …

Genetic integrity of induced pluripotent stem cells (iPSCs) is essential for their validity as
disease models and for potential therapeutic use. We describe the comprehensive analysis …

Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to
our understanding of cell replication and vitality. The proliferation of whole genome …

Conventional approaches to identify a telomere motif in a new genome are laborious and
time-intensive. An efficient new methodology based on next-generation sequencing (NGS) …

(Blackburn & Gall, 1978). They are constituted by tandem repeats of a DNA sequence
whose motif and length varies across species. Their essential functions are to stabilize …

Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to
our understanding of cell replication and vitality. The proliferation of whole genome …

Background: Mutations in proteins involved in telomere maintenance lead to a range of
human diseases, including dyskeratosis congenita, idiopathic pulmonary fibrosis and …