Diagnosis or exclusion of Hirschsprung disease (HSCR) is a frequent exercise in any
pediatric hospital. Although HSCR may present at different ages and with varied clinical …

Objective: Primary gastrointestinal neuropathies are a heterogeneous group of enteric
nervous system (ENS) disorders that continue to cause difficulties in diagnosis and …

Background Hirschsprung's disease (HD) is one of the most common congenital anomalies
of colorectal function, affecting approximately 1 in 5000 live births, with a 4: 1 male …

Hirschsprung disease (HSCR) is a multigenic condition with variable presentation. Most
commonly, it presents in the neonatal period as a functional intestinal obstruction secondary …

Despite significant progress in our understanding of the etiology and pathophysiology of
Hirschsprung disease (HSCR), early and accurate diagnosis and operative management …

Context.—Up to 17% of all rectal suction biopsies performed in the evaluation of
Hirschsprung disease are considered inadequate. In most instances, inadequate biopsies …

Objectives: The detection of ganglion cells in rectal biopsies of infants or toddlers with
severe constipation is routinely performed by pediatric pathologists in many institutions …

Absent calretinin-immunoreactive (CRir) mucosal innervation in aganglionic rectal biopsies
is considered a useful diagnostic finding for Hirschsprung disease. Analysis of a series of …

Rectal suction biopsy (RSB) is a gold standard for diagnosing Hirschsprung disease (HD).
Calretinin staining of RSB is increasingly used by experienced pathologists due to non …

Background: The use of calretinin immunostain (IHC) in the evaluation of rectal suction
biopsies for Hirschsprung disease (HD) has been reported by Kapur et al. and others. The …