Cancer cells are challenged by a myriad of microenvironmental stresses, and it is their
ability to efficiently adapt to the constantly changing nutrient, energy, oxidative, and/or …

Phosphoinositides are low-abundant lipid signaling molecules that govern key cellular
processes including membrane trafficking, cytoskeletal rearrangement, and cell signaling to …

PI5P4Ks are a class of phosphoinositide kinases that phosphorylate PI-5-P to PI-4, 5-P 2.
Distinct localization of phosphoinositides is fundamental for a multitude of cellular functions …

The treatment of acute leukemia is challenging because of the genetic heterogeneity
between and within patients. Leukemic stem cells (LSCs) are relatively drug-resistant and …

The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) play a central role in regulating
cell signalling pathways and, as such, have become therapeutic targets for diseases such as …

While organelles are individual compartments with specialized functions, it is becoming
clear that organellar communication is essential for maintaining cellular homeostasis. This …

The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are therapeutic targets for
diseases such as cancer, neurodegeneration and immunological disorders as they are key …

Background Transcription factor Dp-1 (TFDP1) was overexpressed and interacted with other
genes to impact multiple signaling pathways in various human cancers. However, there is …

Phosphatidylinositol-5-phosphate 4-kinase type 2 (PIP4K2) protein family members
(PIP4K2A, PIP4K2B, and PIP4K2C) participate in the generation of PIP 4, 5 P2, which acts …

The generation of phosphoinositides (PIs) with spatial and temporal control is a key
mechanism in cellular organization and signaling. The synthesis of PIs is mediated by PI …