Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …

The field of stem cells and regenerative medicine offers considerable promise as a means of
delivering new treatments for a wide range of diseases. In order to maximize the …

Integrins are adhesion receptors that allow cells to sense and respond to
microenvironmental signals encoded by the extracellular matrix. They are crucial for the …

Mechanical forces shape biological tissues. They are the effectors of the developmental
programs that orchestrate morphogenesis. A lot of effort has been devoted to understanding …

Variations in a multitude of material microenvironmental properties have been observed
across tissues in vivo, and these have profound effects on cell phenotype …

The ERK-regulated ternary complex factors (TCFs) act with the transcription factor serum
response factor (SRF) to activate mitogen-induced transcription. However, the extent of their …

Abstract Changes in tissue stiffness are frequently associated with diseases such as cancer,
fibrosis, and atherosclerosis. Several recent studies suggest that, in addition to resulting …

Adult stem cells across diverse organs self-renew and differentiate to maintain tissue
homeostasis. How stem cells receive input to preserve tissue structure and function largely …