The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and
possesses unique characteristics that make the delivery of drugs to the brain a great …

Recently, there has been an increasing use of the cyclopropyl ring in drug development to
transition drug candidates from the preclinical to clinical stage. Important features of the …

Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …

The amygdala integrates and processes incoming information pertinent to reward and to
emotions such as fear and anxiety that promote survival by warning of potential danger …

Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …

Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal
loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of
pentameric ligand-gated cation channels that are expressed throughout the brain and …

The past decades have seen a revolution in our understanding of brain diseases and in
particular of drug addiction. This has been largely due to the identification of …

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …