Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …

Abstract Focal Adhesion Kinase (FAK) is a 125-kDa cytoplasmic protein kinase that is
implicated in several cellular functions. This protein is an attractive molecular target for …

Despite the high prognostic value of immune infiltrates in colorectal cancer (CRC),
metastatic disease remains resistant to immunotherapy by immune checkpoint blockade …

Intestinal stem cells (ISC) are crucial players in colon epithelium physiology. The accurate
control of their auto-renewal, proliferation and differentiation capacities provides a constant …

Background & Aims Unregulated activity of interleukin (IL) 22 promotes intestinal
tumorigenesis in mice. IL22 binds the antagonist IL22 subunit alpha 2 (IL22RA2, also called …

The splicing of microexons (very small exons) is frequently dysregulated in the brain of
individuals with autism spectrum disorder. However, little is known of the patterns, regulatory …

FAK, a nonreceptor tyrosine kinase, has been recognized as a novel target class for the
development of targeted anticancer agents. Overexpression of FAK is a common occurrence …

Background Alternative splicing (AS) is an important mechanism of regulating eukaryotic
gene expression. Understanding the most common AS events in colorectal cancer (CRC) …

Mechanobiology comprises how cells perceive different mechanical stimuli and integrate
them into a process called mechanotransduction; therefore, the related mechanosignaling …

RNA splicing is the process of forming mature mRNA, which is an essential phase
necessary for gene expression and controls many aspects of cell proliferation, survival, and …