Protein remote homology detection is one of the most fundamental and central problems for
the studies of protein structures and functions, aiming to detect the distantly evolutionary …

Motivation: Owing to its importance in both basic research (such as molecular evolution and
protein attribute prediction) and practical application (such as timely modeling the 3D …

Protein function prediction is one of the most challenging problems in the post-genomic era.
The number of newly identified proteins has been exponentially increasing with the …

Motivation A large number of newly sequenced proteins are generated by the next-
generation sequencing technologies and the biochemical function assignment of the …

Identification of DNA‐binding proteins is an important problem in biomedical research as
DNA‐binding proteins are crucial for various cellular processes. Currently, the machine …

Protein folds prediction is an essential and basic problem for protein structure and function
research. As far as we see, there are generally three problems for the protein folds …

Motivation: Alignment-free methods for sequence comparison are increasingly used for
genome analysis and phylogeny reconstruction; they circumvent various difficulties of …

Motivation: As more genomes are sequenced, the demand for fast gene classification
techniques is increasing. To analyze a newly sequenced genome, first the genes are …

Motivation: The problems of protein fold recognition and remote homology detection have
recently attracted a great deal of interest as they represent challenging multi-feature multi …

Motivation: Alignment-based methods for sequence analysis have various limitations if large
datasets are to be analysed. Therefore, alignment-free approaches have become popular in …