From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury

CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized …

Biomaterials for neural tissue engineering

LR Doblado, C Martínez-Ramos… - Frontiers in …, 2021 - frontiersin.org
The therapy of neural nerve injuries that involve the disruption of axonal pathways or axonal
tracts has taken a new dimension with the development of tissue engineering techniques …

Concise review: bridging the gap: novel neuroregenerative and neuroprotective strategies in spinal cord injury

CS Ahuja, M Fehlings - Stem cells translational medicine, 2016 - academic.oup.com
Spinal cord injuries (SCIs) result in devastating lifelong disability for patients and their
families. The initial mechanical trauma is followed by a damaging secondary injury cascade …

Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage

R Williams, IM Khan, K Richardson, L Nelson… - PloS one, 2010 - journals.plos.org
Background Articular cartilage displays a poor repair capacity. The aim of cell-based
therapies for cartilage defects is to repair damaged joint surfaces with a functional …

Conditioned medium from bone marrow-derived mesenchymal stem cells improves recovery after spinal cord injury in rats: an original strategy to avoid cell …

D Cantinieaux, R Quertainmont, S Blacher, L Rossi… - PloS one, 2013 - journals.plos.org
Spinal cord injury triggers irreversible loss of motor and sensory functions. Numerous
strategies aiming at repairing the injured spinal cord have been studied. Among them, the …

Repair of injured spinal cord using biomaterial scaffolds and stem cells

B Shrestha, K Coykendall, Y Li, A Moon… - Stem cell research & …, 2014 - Springer
The loss of neurons and degeneration of axons after spinal cord injury result in the loss of
sensory and motor functions. A bridging biomaterial construct that allows the axons to grow …

[HTML][HTML] Multiple strategies enhance the efficacy of MSCs transplantation for spinal cord injury

QM Pang, KQ Deng, M Zhang, XC Wu, RL Yang… - Biomedicine & …, 2023 - Elsevier
Spinal cord injury (SCI) is a serious complication of the central nervous system (CNS) after
spine injury, often resulting in severe sensory, motor, and autonomic dysfunction below the …

Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases

O Sadan, E Melamed, D Offen - Expert opinion on biological …, 2009 - Taylor & Francis
Background: Stem-cell-based therapy is a promising new approach to handling
neurodegenerative diseases. One of the most promising cellular sources is bone-marrow …

GDNF-secreting mesenchymal stem cells provide localized neuroprotection in an inflammation-driven rat model of Parkinson's disease

DB Hoban, L Howard, E Dowd - Neuroscience, 2015 - Elsevier
Constraints involving the delivery method of glial cell line-derived neurotrophic factor
(GDNF) have hampered its efficacy as a neuroprotectant in Parkinson's disease. Ex vivo …