Oxidative stress gene expression profile correlates with cancer patient poor prognosis: identification of crucial pathways might select novel therapeutic approaches
A Leone, MS Roca, C Ciardiello… - Oxidative Medicine …, 2017 - Wiley Online Library
The role of altered redox status and high reactive oxygen species (ROS) is still controversial
in cancer development and progression. Intracellular levels of ROS are elevated in cancer …
in cancer development and progression. Intracellular levels of ROS are elevated in cancer …
Old and new facts and speculations on the role of the B cell receptor in the origin of chronic lymphocytic leukemia
D Bagnara, AN Mazzarello, F Ghiotto… - International Journal of …, 2022 - mdpi.com
The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a
key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and …
key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and …
p53‐independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells
K Sharma, TT Vu, W Cook, M Naseri, K Zhan… - Molecular …, 2018 - Wiley Online Library
The platinum‐based DNA damaging agent cisplatin is used as a standard therapy for locally
advanced head and neck squamous cell carcinoma (HNSCC). However, the mechanisms …
advanced head and neck squamous cell carcinoma (HNSCC). However, the mechanisms …
Apoptosis inducers in chronic lymphocytic leukemia
C Billard - Oncotarget, 2013 - pmc.ncbi.nlm.nih.gov
Chronic lymphocytic leukemia (CLL) is characterized by a typical defect in apoptosis and is
still an incurable disease. Numerous apoptosis inducers have been described. These …
still an incurable disease. Numerous apoptosis inducers have been described. These …
A multidrug approach to modulate the mitochondrial metabolism impairment and relative oxidative stress in fanconi anemia complementation group a
Fanconi Anemia (FA) is a rare recessive genetic disorder characterized by aplastic anemia
due to a defective DNA repair system. In addition, dysfunctional energy metabolism, lipid …
due to a defective DNA repair system. In addition, dysfunctional energy metabolism, lipid …
[HTML][HTML] Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells
S Bruno, B Ledda, C Tenca, S Ravera, AM Orengo… - Oncotarget, 2015 - ncbi.nlm.nih.gov
B-cell chronic lymphocytic leukemia (CLL) was believed to result from clonal accumulation
of resting apoptosis-resistant malignant B lymphocytes. However, it became increasingly …
of resting apoptosis-resistant malignant B lymphocytes. However, it became increasingly …
[HTML][HTML] The passage from bone marrow niche to bloodstream triggers the metabolic impairment in Fanconi Anemia mononuclear cells
E Cappelli, P Degan, S Bruno, F Pierri, M Miano… - Redox biology, 2020 - Elsevier
Fanconi Anemia (FA) is a disease characterized by bone marrow (BM) failure and aplastic
anemia. In addition to a defective DNA repair system, other mechanisms are involved in its …
anemia. In addition to a defective DNA repair system, other mechanisms are involved in its …
[HTML][HTML] A carotenoid-enriched extract from pumpkin delays cell proliferation in a human chronic lymphocytic leukemia cell line through the modulation of autophagic …
Chronic lymphocytic leukemia (CLL) is the most frequent form of leukemia in the adult
population. From an asymptomatic state, which can lay for years, CLL rapidly evolves …
population. From an asymptomatic state, which can lay for years, CLL rapidly evolves …
Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis: role of TNFα, IL-6 and IL-11 cytokines
Bone skeletal alterations are no longer considered a rare event in chronic lymphocytic
leukemia (CLL), especially at more advanced stages of the disease. This study is aimed at …
leukemia (CLL), especially at more advanced stages of the disease. This study is aimed at …
[HTML][HTML] Combining a BCL2 inhibitor with the retinoid derivative fenretinide targets melanoma cells including melanoma initiating cells
N Mukherjee, SN Reuland, Y Lu, Y Luo… - Journal of Investigative …, 2015 - Elsevier
Investigations from multiple laboratories support the existence of melanoma initiating cells
(MICs) that potentially contribute to melanoma's drug resistance. ABT-737, a small molecule …
(MICs) that potentially contribute to melanoma's drug resistance. ABT-737, a small molecule …