With the emergence of RNA sequencing (RNA-seq) technologies, RNA-based biomolecules
hold expanded promise for their diagnostic, prognostic and therapeutic applicability in …

The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …

Activation of normally silent tissue-specific genes and the resulting cell “identity crisis” are
the unexplored consequences of malignant epigenetic reprogramming. We designed a …

The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …

Argonaute proteins were first discovered genetically, and extensive research in the past few
years has revealed that members of the Argonaute protein family are key players in gene …

Small regulatory RNAs such as short interfering RNAs (siRNAs), microRNAs (miRNAs), and
Piwi interacting RNAs (piRNAs) have been discovered in the past, and it is becoming more …

For the many years, the central dogma of molecular biology has been that RNA functions
mainly as an informational intermediate between a DNA sequence and its encoded protein …

Pancreatic cancer is the eighth most common cancer and has an overall 5‐year survival rate
lower than 10%. Because of their ability to regulate gene expression, microRNAs can act as …

Abstract Background Piwi-interacting RNAs (piRNAs) are a novel class of non-coding single
strand RNAs. They are involved in germline development, in silencing of selfish DNA …

The topipotency of the germline is the full manifestation of the pluri-and multipotency of
embryonic and adult stem cells, thus the germline and stem cells must share common …