Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis

ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

The purinergic system as a pharmacological target for the treatment of immune-mediated inflammatory diseases

L Antonioli, C Blandizzi, P Pacher, G Haskó - Pharmacological reviews, 2019 - ASPET
Immune-mediated inflammatory diseases (IMIDs) encompass a wide range of seemingly
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …

The roles of adenosine deaminase in autoimmune diseases

Z Gao, X Wang, H Zhang, F Lin, C Liu, K Dong - Autoimmunity Reviews, 2021 - Elsevier
Autoimmune diseases patients are characterized by the autoimmune disorders, whose
immune system can't distinguish between auto-and foreign-antigens. Thus, Immune …

Oxidative stress marker aberrations in multiple sclerosis: A meta-analysis study

SY Zhang, LN Gui, YY Liu, S Shi, Y Cheng - Frontiers in neuroscience, 2020 - frontiersin.org
Oxidative stress has been suggested to play a key role in multiple sclerosis (MS), but clinical
data on oxidative stress markers in MS patients were inconsistent. This study sought to …

Probiotic supplementation and systemic inflammation in relapsing-remitting multiple sclerosis: A randomized, double-blind, placebo-controlled trial

M Rahimlou, S Nematollahi, D Husain… - Frontiers in …, 2022 - frontiersin.org
Background Multiple sclerosis (MS) is a complex inflammatory disease in which
demyelination occurs in the central nervous system affecting approximately 2.5 million …

Adenosine deaminase inhibition

S Bagheri, AA Saboury, T Haertlé - International Journal of Biological …, 2019 - Elsevier
Adenosine deaminase is a critical enzyme in purine metabolism that regulates intra and
extracellular adenosine concentrations by converting it to inosine. Adenosine is an important …

[HTML][HTML] MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: relevance of GNbAC1 in multiple sclerosis treatment

A Madeira, I Burgelin, H Perron, F Curtin… - Journal of …, 2016 - Elsevier
Multiple sclerosis associated retrovirus envelope protein (MSRV-Env) was repeatedly
detected in brain lesions and blood of multiple sclerosis (MS) patients. We performed the …

Epitranscriptomic modifications modulate normal and pathological functions in CNS

AK Chokkalla, SL Mehta, R Vemuganti - Translational stroke research, 2022 - Springer
RNA is more than just a combination of four genetically encoded nucleobases as it carries
extra information in the form of epitranscriptomic modifications. Diverse chemical groups …

Exploring the role of neurotransmitters in multiple sclerosis: an expanded review

E Akyuz, BR Celik, FS Aslan, H Sahin… - ACS Chemical …, 2023 - ACS Publications
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system (CNS). Although emerging evidence has shown that changes in …

Possible role of butyrylcholinesterase in fat loss and decreases in inflammatory levels in patients with multiple sclerosis after treatment with epigallocatechin gallate …

JE de la Rubia Ortí, JL Platero, IH Yang, JJ Ceron… - Nutrients, 2021 - mdpi.com
(1) Background. Multiple sclerosis (MS) is characterised by the loss of muscle throughout the
course of the disease, which in many cases is accompanied by obesity and related to …