Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Despite enormous advances, cardiovascular disorders are still a major threat to global
health and are responsible for one-third of deaths worldwide. Research for new therapeutics …

Bone defects stemming from tumorous growths, traumatic events, and diverse conditions
present a profound conundrum in clinical practice and research. While bone has the …

Osteoarthritis (OA) is a chronic disease that causes pain and disability in adults, affecting≈
300 million people worldwide. It is caused by damage to cartilage, including cellular …

Bone is one of the key components of the musculoskeletal system. Bone and joint disease
are the fourth most widespread disease, in addition to cardiovascular disease, cancer, and …

The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a
method for generating complex BM-like organoids (BMOs) from human induced pluripotent …

Bioengineered models of human tissues have the potential to revolutionize human health by
providing a translational platform to investigate disease mechanisms and develop new …

The bone marrow supports and regulates hematopoiesis, responding to physiological
requirements for blood cell production over ontogeny and during pathological challenges …

Cancer therapies have several clinical challenges associated with them, namely treatment
toxicity, treatment resistance and relapse. Due to factors ranging from patient profiles to the …

Early B cell development in the bone marrow ensures the replenishment of the peripheral B
cell pool. Immature B cells continuously develop from hematopoietic stem cells, in a process …