▪ Abstract At the interface between the innate and adaptive immune systems lies the high-
output isoform of nitric oxide synthase (NOS2 or iNOS). This remarkable molecular machine …

This review focuses on the production of nitric oxide (NO) by inducible nitric oxide synthase
(iNOS) and its regulation under physiological and pathophysiological conditions. NO is an …

Rab proteins are generally required for transport vesicle docking. We have exploited yeast
secretion mutants to demonstrate that a rab protein is required for v-SNAREs and t-SNAREs …

Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …

Nitric oxide (NO) is a potent biologic mediator with diverse physiologic and pathophysiologic
roles. NO is produced from L-arginine by the family of nitric oxide synthase (NOS) enzymes …

Three isozymes of nitric oxide synthase (NOS) have been identified. Their cDNA-and protein
structures as well as their genomic DNA structures have been described. NOS I (ncNOS …

Fibroblast differentiation to the myofibroblast phenotype is associated with α–smooth-muscle
actin (α-SMA) expression and regulated by cytokines. Among these, transforming growth …

Excess vascular smooth muscle cell (VSMC) proliferation and contractility are key events in
the pathophysiology of vascular disorders induced by hypoxia. We have recently reported …

Glucocorticoids (GCS) profoundly inhibit several aspects of T cell immunity largely through
inhibition of cytokine expression at the transcriptional and posttranscriptional levels. GCS …

The different cell types comprising cardiac muscle express one or more of the three isoforms
(neuronal NOS, or nNOS; inducible NOS, or iNOS; and endothelial NOS, or eNOS) of nitric …