Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back
pain (LBP), causing a significant global disability. The IVD consists of an inner core …

Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and
chronic condition that has a striking effect on quality of life. Currently, no approved …

Lumbar disc degeneration is one of the leading causes of chronic low back pain. The
degenerative cascade is often initiated by an imbalance between catabolic and anabolic …

To help doctors and patients evaluate lumbar intervertebral disc degeneration (IVDD)
accurately and efficiently, we propose a segmentation network and a quantitation method for …

Objective Back pain is an elusive symptom complicated by a variety of possible causes,
precipitating and maintaining factors, and consequences. Notably, the underlying pathology …

The healthy intervertebral disc (IVD) fulfils the essential function of load absorption, while
maintaining multi-axial flexibility of the spine. The interrelated tissues of the IVD, the annulus …

The purpose of this review was to evaluate data generated by animal models of
intervertebral disc (IVD) degeneration published in the last decade and show how this has …

Intervertebral disc degeneration (IVDD) has been the major contributor to chronic lower back
pain (LBP). Abnormal apoptosis, senescence, and pyroptosis of IVD cells, extracellular …

Although degeneration of the nucleus pulposus (NP) is a major contributor to intervertebral
disc degeneration (IVDD) and low back pain, the underlying molecular complexity and …