Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Lipid droplets in chordates are decorated by two or more members of the perilipin family of
lipid droplet surface proteins. The perilipins sequester lipids by protecting lipid droplets from …

How proteins specifically localize to the phospholipid monolayer surface of lipid droplets
(LDs) is being unraveled. We review here the major known pathways of protein targeting to …

Aims/hypothesis We aimed to elucidate the impact of fat cell size and inflammatory status of
adipose tissue on the development of type 2 diabetes in non-obese individuals. Methods We …

The discovery by Dr. Constantine Londos of perilipin 1, the major scaffold protein at the
surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in …

Lipodystrophies are the result of a range of inherited and acquired causes, but all are
characterized by perturbations in white adipose tissue function and, in many instances, its …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

Lipid droplets (LDs) are ubiquitous cellular organelles for lipid storage which are composed
of a neutral lipid core bounded by a protein decorated phospholipid monolayer. Although …

Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on
the surface of lipid droplets. Failure of this activity results in severe metabolic disease in …

Abstract Purpose of Review Genetic or acquired lipodystrophies are characterized by
selective loss of body fat along with predisposition towards metabolic complications of …