The broad spectrum of human natural killer cell diversity
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …
Regulation of the immune response by TGF-β: from conception to autoimmunity and infection
Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in both suppressive
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma
Background and aims Chronic inflammation induced by chronic hepatitis B virus (HBV)
infection increases the risk of hepatocellular carcinoma (HCC). However, little is known …
infection increases the risk of hepatocellular carcinoma (HCC). However, little is known …
[PDF][PDF] Human CD96 correlates to natural killer cell exhaustion and predicts the prognosis of human hepatocellular carcinoma
H Sun, Q Huang, M Huang, H Wen, R Lin… - …, 2019 - Wiley Online Library
Immune checkpoint blockade has become a promising therapeutic approach to reverse
immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin and ITIM domain …
immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin and ITIM domain …
Developmental and functional control of natural killer cells by cytokines
Y Wu, Z Tian, H Wei - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …
NK cell exhaustion
J Bi, Z Tian - Frontiers in immunology, 2017 - frontiersin.org
Natural killer cells are important effector lymphocytes of the innate immune system, playing
critical roles in antitumor and anti-infection host defense. Tumor progression or chronic …
critical roles in antitumor and anti-infection host defense. Tumor progression or chronic …
Immune responses and immunopathology in acute and chronic viral hepatitis
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer
C Sun, J Xu, Q Huang, M Huang, H Wen… - …, 2017 - Taylor & Francis
ABSTRACT Background and Aims: As the predominant lymphocyte subset in the liver,
natural killer (NK) cells have been shown to be highly associated with the outcomes of …
natural killer (NK) cells have been shown to be highly associated with the outcomes of …
NK cell dysfunction and checkpoint immunotherapy
J Bi, Z Tian - Frontiers in immunology, 2019 - frontiersin.org
NK cells play important roles in the innate immune responses against tumors. The effector
function of NK cells relies on the integration of activating and inhibitory signals. Emerging …
function of NK cells relies on the integration of activating and inhibitory signals. Emerging …
Pathogenicity and virulence of Hepatitis B virus
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are
an estimated 296 million people in the world that are chronically infected by this virus, and …
an estimated 296 million people in the world that are chronically infected by this virus, and …