Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: a possible GABAergic …
Quercetin is the most common polyphenolic flavonoid present in fruits and vegetables
demonstrating versatile health‐promoting effects. This study aimed to examine the effects of …
demonstrating versatile health‐promoting effects. This study aimed to examine the effects of …
The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors
VB Kasaragod, T Malinauskas, AA Wahid… - Nature Structural & …, 2023 - nature.com
Abstract α5 subunit-containing γ-aminobutyric acid type A (GABAA) receptors represent a
promising drug target for neurological and neuropsychiatric disorders. Altered expression …
promising drug target for neurological and neuropsychiatric disorders. Altered expression …
Advances in targeting neurotransmitter systems in dystonia
D Steel, KM Reid, A Pisani, EJ Hess, S Fox… - International Review of …, 2023 - Elsevier
Dystonia is characterised as uncontrolled, often painful involuntary muscle contractions that
cause abnormal postures and repetitive or twisting movements. These movements can be …
cause abnormal postures and repetitive or twisting movements. These movements can be …
Epileptic Encephalopathy GABRB Structural Variants Share Common Gating and Trafficking Defects
CC Hernandez, N Hu, W Shen, RL Macdonald - Biomolecules, 2023 - mdpi.com
Variants in the GABRB gene, which encodes the β subunit of the GABAA receptor, have
been implicated in various epileptic encephalopathies and related neurodevelopmental …
been implicated in various epileptic encephalopathies and related neurodevelopmental …
Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression
J Zhu, X Jiang, Z Li, S Liu, J Han, S Li, Z Liu… - Bioorganic …, 2025 - Elsevier
Intravenous anesthetics play a crucial role during surgery. Etomidate, a commonly used
intravenous anesthetic agent, is prized for its rapid onset and smooth induction of …
intravenous anesthetic agent, is prized for its rapid onset and smooth induction of …
GABAA and serotonergic receptors participation in anxiolytic effect of chalcones in adult zebrafish
FRS Mendes, AW da Silva, MKA Ferreira… - Journal of …, 2023 - Taylor & Francis
The prevalence of anxiety is a significant public health problem, being the 24th leading
cause of disability in individuals affected by this disorder. In this context, chalcones, a …
cause of disability in individuals affected by this disorder. In this context, chalcones, a …
Increased Pneumonia Risk Associated with Concomitant Use of Inhaled Corticosteroids and Benzodiazepines: A Pharmacovigilance Analysis
J Ma, Y Liu, Y Sun, C Guo, G Yang - Lung, 2024 - Springer
Background Inhaled corticosteroids (ICS) are effective in managing asthma and chronic
obstructive pulmonary disease (COPD) but increase the risk of pneumonia …
obstructive pulmonary disease (COPD) but increase the risk of pneumonia …
Treating Aggressive Behavior in Psychiatric Inpatients: The Efficacy of Different GABAergic Agents, Benzodiazepines, and Z Drugs
A Ceccherini-Nelli, J Orris - Handbook of Anger, Aggression, and Violence, 2023 - Springer
GABAA receptor positive allosteric modulators (PAM), such as benzodiazepines, may either
reduce or enhance violence. This review of the literature found evidence that lorazepam …
reduce or enhance violence. This review of the literature found evidence that lorazepam …
Design and Synthesis of Chiral and Achiral Benzodiazepines and Imidazodiazepines as α–Subtype Selective Gabaar Positive Modulators to Treat Schistosomiasis …
Y Mian - 2022 - search.proquest.com
DESIGN AND SYNTHESIS OF CHIRAL AND ACHIRAL BENZODIAZEPINES AND
IMIDAZODIAZEPINES AS α–SUBTYPE SELECTIVE GABAAR POSITIVE MODUL Page 1 DESIGN …
IMIDAZODIAZEPINES AS α–SUBTYPE SELECTIVE GABAAR POSITIVE MODUL Page 1 DESIGN …