Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation
Two of nature's recurring binding motifs in metalloproteins are the CxxxCxxC motif in radical
SAM enzymes and the 2-His-1-carboxylate motif found both in zincins and α-ketoglutarate …
SAM enzymes and the 2-His-1-carboxylate motif found both in zincins and α-ketoglutarate …
Mechanistic Insights Into Post‐translational α‐Keto‐β‐Amino Acid Formation by a Radical S‐Adenosyl Methionine Peptide Splicease
AL Vagstad, E Lakis, KS Csizi, W Walls… - Angewandte Chemie …, 2024 - Wiley Online Library
Radical S‐adenosyl methionine enzymes catalyze a diverse repertoire of post‐translational
modifications in protein and peptide substrates. Among these, an exceptional and …
modifications in protein and peptide substrates. Among these, an exceptional and …
The Triceptide Maturase OscB Catalyzes Uniform Cyclophane Topology and Accepts Diverse Gly-Rich Precursor Peptides
M Purushothaman, L Chang, RJ Zhong… - ACS Chemical …, 2024 - ACS Publications
Triceptides are a class of ribosomally synthesized and post-translationally modified peptides
defined by an aromatic C (sp2) to Cβ (sp3) bond. The Gly-rich repeat family of triceptide …
defined by an aromatic C (sp2) to Cβ (sp3) bond. The Gly-rich repeat family of triceptide …