[HTML][HTML] Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer
EH Ervin, R French, CH Chang, S Pauklin - Seminars in cancer biology, 2022 - Elsevier
Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
Comprehensive profiling of genomic and transcriptomic differences between risk groups of lung adenocarcinoma and lung squamous cell carcinoma
T Zengin, T Önal-Süzek - Journal of personalized medicine, 2021 - mdpi.com
Lung cancer is the second most frequently diagnosed cancer type and responsible for the
highest number of cancer deaths worldwide. Lung adenocarcinoma (LUAD) and lung …
highest number of cancer deaths worldwide. Lung adenocarcinoma (LUAD) and lung …
MYCN amplification is associated with reduced expression of genes encoding γ-secretase complex and NOTCH signaling components in neuroblastoma
Amplification of the MYCN oncogene is found in~ 20% of neuroblastoma (NB) cases and
correlates with high-risk disease and poor prognosis. Despite the plethora of studies …
correlates with high-risk disease and poor prognosis. Despite the plethora of studies …
Gene Regulatory Network of ETS Domain Transcription Factors in Different Stages of Glioma
The ETS domain family of transcription factors is involved in a number of biological
processes, and is commonly misregulated in various forms of cancer. Using microarray …
processes, and is commonly misregulated in various forms of cancer. Using microarray …
Recent developments in cancer systems biology: Lessons learned and future directions
Cancer is a complex disease involving multiple mechanisms and critical players, at broad
genomic, transcriptional, translational and/or biochemical levels. One could envision …
genomic, transcriptional, translational and/or biochemical levels. One could envision …
Mitotic Kinases Aurora‐A, Plk1, and Cdk1 Interact with Elk‐1 Transcription Factor through the N‐Terminal Domain
Elk‐1 is a member of the ETS domain transcription factor superfamily that is phosphorylated
upon mitogen‐activated protein kinase (MAPK) pathway activation, which in turn regulated …
upon mitogen‐activated protein kinase (MAPK) pathway activation, which in turn regulated …
Nervous system-related gene regulatory networks and functional evolution of ETS proteins across species
The ETS domain transcription factor family is one of the major transcription factor
superfamilies that play regulatory roles in development, cell growth, and cancer progression …
superfamilies that play regulatory roles in development, cell growth, and cancer progression …
[HTML][HTML] GPD2: the relationship with cancer and neural stemness
M Mikeli, M Fujikawa, T Tanabe - Cells & Development, 2023 - Elsevier
We previously reported that knocking down GPD2 (glycerol-3-phosphate dehydrogenase 2),
responsible for the glycerol-phosphate shuttle, causes human hepatocarcinoma-derived …
responsible for the glycerol-phosphate shuttle, causes human hepatocarcinoma-derived …
BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles
In developing Xenopus tadpoles, the optic tectum begins to receive patterned visual input
while visuomotor circuits are still undergoing neurogenesis and circuit assembly. This visual …
while visuomotor circuits are still undergoing neurogenesis and circuit assembly. This visual …
[HTML][HTML] ELK1 在恶性肿瘤中的作用及调控机制的研究进展
何姣， 韩志刚， 俞婷婷 - Advances in Clinical Medicine, 2024 - hanspub.org
ETS 蛋白质家族由28 个转录因子组成, ELK1 是ETS 转录因子家族和三元复合因子(ternary
complex factor, TCF) 亚家族成员. 越来越多的研究显示, ELK1 参与多种分子生物学进程 …
complex factor, TCF) 亚家族成员. 越来越多的研究显示, ELK1 参与多种分子生物学进程 …