Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease
L Jia, J Piña-Crespo, Y Li - Molecular brain, 2019 - Springer
Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …
[HTML][HTML] Deep multilayer brain proteomics identifies molecular networks in Alzheimer's disease progression
Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We
characterize AD stage-associated molecular networks by profiling 14,513 proteins and …
characterize AD stage-associated molecular networks by profiling 14,513 proteins and …
Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease
Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying
mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac …
mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac …
Neuroinflammation in schizophrenia: the key role of the WNT/β-catenin pathway
A Vallée - International Journal of Molecular Sciences, 2022 - mdpi.com
Schizophrenia is a very complex syndrome involving widespread brain multi-
dysconnectivity. Schizophrenia is marked by cognitive, behavioral, and emotional …
dysconnectivity. Schizophrenia is marked by cognitive, behavioral, and emotional …
Physiology and pharmacology of amyloid precursor protein
Y Cho, HG Bae, E Okun, TV Arumugam… - Pharmacology & …, 2022 - Elsevier
Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …
Regulatory T cells delay disease progression in Alzheimer-like pathology
C Dansokho, D Ait Ahmed, S Aid, C Toly-Ndour… - Brain, 2016 - academic.oup.com
Recent studies highlight the implication of innate and adaptive immunity in the
pathophysiology of Alzheimer's disease, and foster immunotherapy as a promising strategy …
pathophysiology of Alzheimer's disease, and foster immunotherapy as a promising strategy …
Role of Wnt signaling in adult hippocampal neurogenesis in health and disease
SB Arredondo, D Valenzuela-Bezanilla… - Frontiers in Cell and …, 2020 - frontiersin.org
Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals
provided by the local hippocampal microenvironment support neural stem cell proliferation …
provided by the local hippocampal microenvironment support neural stem cell proliferation …
Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's disease
A Vallée, Y Lecarpentier, R Guillevin… - Acta biochimica et …, 2017 - academic.oup.com
Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology
remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary …
remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary …