RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures,
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …

It has been more than 50 years since the elucidation of the structure of double-helical DNA.
Despite active research and progress in DNA biology and biochemistry, much remains to be …

Cytoskeletal elements, like actin and myosin, have been reconstituted inside lipid vesicles
toward the vision to reconstruct cells from the bottom up. Here, we realize the de novo …

Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics
for undergraduate or graduate students. It maps the huge and complex landscape of cell …

Biological semiflexible polymers and filaments such as collagen, fibronectin, actin,
microtubules, coiled-coil proteins, DNA, siRNA, amyloid fibrils, etc., are ubiquitous in nature …

The classical view of DNA posits that DNA must be stiff below the persistence length [< 150
base pairs (bp)], but recent studies addressing this have yielded contradictory results. We …

We study the distance-dependent quenching of fluorescence due to a metallic nanoparticle
in proximity of a fluorophore. In our single-molecule measurements, we achieve excellent …

Equilibrium knots are common in biological polymers—their prevalence, size distribution,
structure, and dynamics have been extensively studied, with implications to fundamental …

The study of the conformation properties of macromolecules is at the heart of polymer
science. Essentially all physical properties of polymers are manifestations of the underlying …

RNA plays myriad roles in the transmission and regulation of genetic information that are
fundamentally constrained by its mechanical properties, including the elasticity and …