The widespread use of molecular machines in biology has long suggested that great
rewards could come from bridging the gap between synthetic molecular systems and the …

Conspectus Host–guest chemistry commenced to a large degree with the work of Pedersen,
who in 1967 first reported the synthesis of crown ethers. The past 45 years have witnessed a …

Conspectus Research on nanoparticles has evolved into a major topic in chemistry.
Concerning biomedical research, nanoparticles have decisively entered the field, creating …

Macrocyclic peptides can interfere with challenging biomolecular targets including protein–
protein interactions. Whereas there are various approaches that facilitate the identification of …

Proteins typically interact with multiple binding partners, and often different parts of their
surfaces are employed to establish these protein–protein interactions (PPIs). Members of the …

In type-2 diabetes (T2D), islet amyloid polypeptide (IAPP) self-associates into toxic
assemblies causing islet β-cell death. Therefore, preventing IAPP toxicity is a promising …

Although the precise molecular factors linking amyloid β-protein (Aβ) to Alzheimer's disease
(AD) have not been deciphered, interaction of Aβ with cellular membranes has an important …

Giardiasis is a gastrointestinal diarrheal illness caused by the protozoan parasite Giardia
duodenalis, which affects annually over 200 million people worldwide. The limited …

The tumor suppressor p53 plays a unique role as a central hub of numerous cell
proliferation and apoptotic pathways, and its malfunction due to mutations is a major cause …

The deviant Ras activation machinery is found in approximately 30% of all human cancers.
SOS1 is an important protagonist of this pathway that plays a key-role in aberrant cell …