The degree of frailty as a translational measure of health in aging

SE Howlett, AD Rutenberg, K Rockwood - Nature Aging, 2021 - nature.com
Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Frailty and multimorbidity: a systematic review and meta-analysis

DL Vetrano, K Palmer, A Marengoni… - The Journals of …, 2019 - academic.oup.com
Background Multimorbidity and frailty are complex syndromes characteristics of aging. We
reviewed the literature and provided pooled estimations of any evidence regarding (a) the …

Frailty in older persons

M Cesari, R Calvani, E Marzetti - Clinics in geriatric …, 2017 - geriatric.theclinics.com
The number of scientific publications on frailty has been increasing exponentially during the
past 15 years (Fig. 1). Studies on the topic are not limited to the geriatric and gerontology …

Ageing and inflammation in patients with HIV infection

M Nasi, S De Biasi, L Gibellini… - Clinical & …, 2017 - academic.oup.com
Nowadays, HIV+ patients have an expected lifespan that is only slightly shorter than healthy
individuals. For this reason, along with the fact that infection can be acquired at a relatively …

Frailty in older people living with HIV: current status and clinical management

DS Kehler, J Milic, G Guaraldi, T Fulop, J Falutz - BMC geriatrics, 2022 - Springer
This paper will update care providers on the clinical and scientific aspects of frailty which
affects an increasing proportion of older people living with HIV (PLWH). The successful use …

Frailty and solid-organ transplant candidates: a scoping review

J Kao, N Reid, RE Hubbard, R Homes, LS Hanjani… - BMC geriatrics, 2022 - Springer
Background There is currently no consensus as to a standardized tool for frailty
measurement in any patient population. In the solid-organ transplantation population …

Measuring frailty in younger populations: a rapid review of evidence

GF Spiers, TP Kunonga, A Hall, F Beyer, E Boulton… - BMJ open, 2021 - bmjopen.bmj.com
Objectives Frailty is typically assessed in older populations. Identifying frailty in adults aged
under 60 years may also have value, if it supports the delivery of timely care. We sought to …

Aging, frailty and complex networks

AB Mitnitski, AD Rutenberg, S Farrell, K Rockwood - Biogerontology, 2017 - Springer
When people age their mortality rate increases exponentially, following Gompertz's law.
Even so, individuals do not die from old age. Instead, they accumulate age-related illnesses …

HIV infection is independently associated with frailty in middle-aged HIV type 1-infected individuals compared with similar but uninfected controls

KW Kooij, FWNM Wit, J Schouten, M van der Valk… - Aids, 2016 - journals.lww.com
Background: Frailty is an age-related syndrome of decreased physiological reserve and
resistance to stressors, associated with increased morbidity and mortality in the general …

Baseline characteristics and comorbidities in the CAnadian REgistry for Pulmonary Fibrosis

JH Fisher, M Kolb, M Algamdi, J Morisset… - BMC pulmonary …, 2019 - Springer
Abstract Background The CAnadian REgistry for Pulmonary Fibrosis (CARE-PF) is a multi-
center, prospective registry designed to study the natural history of fibrotic interstitial lung …