Mechanisms and regulation of protein synthesis in mitochondria

E Kummer, N Ban - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

Organization and expression of the mammalian mitochondrial genome

O Rackham, A Filipovska - Nature Reviews Genetics, 2022 - nature.com
The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …

Cancer metabolism: a therapeutic perspective

UE Martinez-Outschoorn, M Peiris-Pagés… - Nature reviews Clinical …, 2017 - nature.com
Awareness that the metabolic phenotype of cells within tumours is heterogeneous—and
distinct from that of their normal counterparts—is growing. In general, tumour cells …

Mitochondrial diseases: the contribution of organelle stress responses to pathology

A Suomalainen, BJ Battersby - Nature reviews Molecular cell biology, 2018 - nature.com
Mitochondrial diseases affect one in 2,000 individuals; they can present at any age and they
can manifest in any organ. How defects in mitochondria can cause such a diverse range of …

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

BA Barad, N Echols, RYR Wang, Y Cheng, F DiMaio… - Nature …, 2015 - nature.com
Advances in high-resolution cryo-electron microscopy (cryo-EM) require the development of
validation metrics to independently assess map quality and model geometry. We report …

Mitochondrial transcription and translation: overview

AR D'Souza, M Minczuk - Essays in biochemistry, 2018 - portlandpress.com
Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the
inner membrane of the organelle are involved in the oxidative phosphorylation required for …

Mitochondrial genome engineering: the revolution may not be CRISPR-Ized

PA Gammage, CT Moraes, M Minczuk - Trends in Genetics, 2018 - cell.com
In recent years mitochondrial DNA (mtDNA) has transitioned to greater prominence across
diverse areas of biology and medicine. The recognition of mitochondria as a major …

Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta

RYR Wang, Y Song, BA Barad, Y Cheng, JS Fraser… - Elife, 2016 - elifesciences.org
Cryo-EM has revealed the structures of many challenging yet exciting macromolecular
assemblies at near-atomic resolution (3–4.5 Å), providing biological phenomena with …

Architecture of the mammalian mechanosensitive Piezo1 channel

J Ge, W Li, Q Zhao, N Li, M Chen, P Zhi, R Li, N Gao… - Nature, 2015 - nature.com
Piezo proteins are evolutionarily conserved and functionally diverse mechanosensitive
cation channels. However, the overall structural architecture and gating mechanisms of …

Structure of the human 80S ribosome

H Khatter, AG Myasnikov, SK Natchiar, BP Klaholz - Nature, 2015 - nature.com
Ribosomes are translational machineries that catalyse protein synthesis. Ribosome
structures from various species are known at the atomic level, but obtaining the structure of …