Bone defects pose a heavy burden on patients, orthopedic surgeons, and public health
resources. Various pathological conditions cause bone defects including trauma, tumors …

Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

High‐throughput methods to profile the genome, transcriptome, proteome and metabolome
of various systems has become a routine in multiple research laboratories around the world …

Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

Osteoporosis is caused by the disruption in homeostasis between bone formation and bone
resorption. Conventional management of osteoporosis involves systematic drug …

Osteoporosis is one of the major bone disorders that affects both women and men, and
causes bone deterioration and bone strength. Bone remodeling maintains bone mass and …

The excessive accumulation of reactive oxygen species (ROS) under osteoporosis
precipitates a microenvironment with high levels of oxidative stress (OS). This could …

Multi-omics studies, which explore the interactions between multiple types of biological
factors, have significant advantages over single-omics analysis for their ability to provide a …

Depression is a high risk for osteoporosis, suggesting an association between depression
and low bone mineral density (BMD). We reported that the novel antidepressant (R) …