Plant cells accumulate small RNA molecules that regulate plant development, genome
stability, and environmental responses. These small RNAs fall into three major classes …

MicroRNAs are small RNAs, 20–22 nt long, the main role of which is to downregulate gene
expression at the level of mRNAs. MiRNAs are fundamental regulators of plant growth and …

Centromeres are the specialized regions of the chromosomes that direct faithful
chromosome segregation during cell division. Despite their functional conservation …

The methyltransferase complex (MTC) deposits N 6-adenosine (m6A) onto RNA, whereas
the microprocessor produces microRNA. Whether and how these two distinct complexes …

For many years we have studied the processes involved in producing miRNAs in plants and
the numerous differences from their metazoan counterpart. A well-defined catalytic process …

MicroRNAs (miRNAs) are produced from highly structured primary transcripts (pri-miRNAs)
and regulate numerous biological processes in eukaryotes. Due to the extreme …

The activities of RNA polymerases shape the epigenetic landscape of genomes with
profound consequences for genome integrity and gene expression. A fundamental event …

Long non-coding RNAs (lncRNAs) are a group of RNAs greater than 200 nucleotides in
length exhibiting low or no coding potential that are involved in diverse biological functions …

RNA helicases (RHs) are a family of ubiquitous enzymes that alter RNA structures and
remodel ribonucleoprotein complexes typically using energy from the hydrolysis of ATP …

BRCA1-deficient cells have increased IRE1 RNase, which degrades multiple microRNAs.
Reconstituting expression of one of these, miR-4638–5p, resulted in synthetic lethality in …