Going circular: history, present, and future of circRNAs in cancer
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
Aging, melatonin, and the pro-and anti-inflammatory networks
R Hardeland - International journal of molecular sciences, 2019 - mdpi.com
Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …
Targeting mitochondria-located circRNA SCAR alleviates NASH via reducing mROS output
Q Zhao, J Liu, H Deng, R Ma, JY Liao, H Liang, J Hu… - Cell, 2020 - cell.com
Mitochondria, which play central roles in immunometabolic diseases, have their own
genome. However, the functions of mitochondria-located noncoding RNAs are largely …
genome. However, the functions of mitochondria-located noncoding RNAs are largely …
The landscape of circular RNA in cancer
Circular RNAs (circRNAs) are an intriguing class of RNA due to their covalently closed
structure, high stability, and implicated roles in gene regulation. Here, we used an exome …
structure, high stability, and implicated roles in gene regulation. Here, we used an exome …
[HTML][HTML] A network of noncoding regulatory RNAs acts in the mammalian brain
Noncoding RNAs (ncRNAs) play increasingly appreciated gene-regulatory roles. Here, we
describe a regulatory network centered on four ncRNAs—a long ncRNA, a circular RNA …
describe a regulatory network centered on four ncRNAs—a long ncRNA, a circular RNA …
Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression
Extracellular communication in the tumor microenvironment is critical. Results of qRT-PCR
show that circ-0051443 is significantly lower in the plasma exosomes and tissues from …
show that circ-0051443 is significantly lower in the plasma exosomes and tissues from …
[HTML][HTML] Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271
HF Liang, XZ Zhang, BG Liu, GT Jia… - American journal of …, 2017 - ncbi.nlm.nih.gov
Circular RNA (circRNA) is a key regulator in the development and progression of human
cancers, however its role in breast cancer tumorigenesis is not well understood. The present …
cancers, however its role in breast cancer tumorigenesis is not well understood. The present …
Molecular roles and function of circular RNAs in eukaryotic cells
LM Holdt, A Kohlmaier, D Teupser - Cellular and Molecular Life Sciences, 2018 - Springer
Protein-coding and noncoding genes in eukaryotes are typically expressed as linear
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …
A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1
B Zhou, JW Yu - Biochemical and biophysical research communications, 2017 - Elsevier
Circular RNAs (circRNAs) are a novel type of endogenous noncoding RNA gaining research
interest in recent years. Despite this increase in interest, the mechanism of circRNAs in the …
interest in recent years. Despite this increase in interest, the mechanism of circRNAs in the …
[HTML][HTML] Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets
C Wang, Z Li, Y Liu, L Yuan - Theranostics, 2021 - ncbi.nlm.nih.gov
Exosomes are nanosized lipid vesicles originating from the endosomal system that carry
many macromolecules from their parental cells and play important roles in intercellular …
many macromolecules from their parental cells and play important roles in intercellular …