Nicotine achieves its psychopharmacological effects by interacting with nicotinic
acetylcholine receptors (nAChRs) in the brain. There are numerous subtypes of nAChR that …

While most cigarette smokers endorse a desire to quit smoking, only 14–49% will achieve
abstinence after 6 months or more of treatment. A greater understanding of the effects of …

Background Alzheimer's disease (AD) is the most common form of dementia in older adults
that damages the brain and results in impaired memory, thinking and behaviour. The …

Discovering effective therapies is difficult for neurological and developmental disorders in
that disease progression is often associated with a complex and interactive mechanism …

Background Nicotine intake induces addiction through neuroplasticity of the reward circuitry,
altering the activity of dopaminergic neurons of the ventral tegmental area. Prior work …

It has been several decades since synaptic dysfunction was first suggested to play a role in
schizophrenia, but only in the last few years has convincing evidence been obtained as …

Abstract Small-conductance Ca 2+-activated K+(K Ca 2) channels control neuronal
excitability and synaptic plasticity, and have been implicated in substance abuse. However …

Nicotine, the major psychoactive component of cigarette smoke, modulates neuronal activity
to produce Ca2+‐dependent changes in gene transcription. However, the downstream …

Nuclear receptor subfamily 1, group D, member 1 (Nr1d1)(also known as Rev‐erb alpha)
has been linked to circadian rhythm regulation, mood‐related behaviour and disorders …

Cross-species translational approaches to human genomic analyses are lacking. The
present study uses an integrative framework to investigate how genes associated with …