Bladder cancer, specifically, muscle-invasive bladder cancer (MIBC), is among the most
common malignant tumors. Patients with MIBC who cannot tolerate standard drugs require …

DNA repair and DNA damage signaling pathways are critical for the maintenance of
genomic stability. Defects of DNA repair and damage signaling contribute to tumorigenesis …

Conventional chondrosarcoma of the chest wall is rare, accounting for 15% of cases. Our
purpose was to document clinicopathological, imaging and outcome results from a novel set …

Triple-negative breast cancer (TNBC) can be further classified into androgen receptor (AR)-
positive TNBC and AR-negative TNBC or quadruple-negative breast cancer (QNBC). Here …

Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor that originates from bile duct's
epithelial cells and is usually characterized by insidious symptoms and poor prognosis …

The MRE11, RAD50, and NBN genes encode for the nuclear MRN protein complex, which
senses the DNA double strand breaks and initiates the DNA repair. The MRN complex also …

Thyroid carcinoma (TC) can be classified as medullary (MTC) and non-medullary (NMTC).
While most TCs are sporadic, familial forms of MTC and NMTC also exist (less than 1% and …

Breast cancer, more prevalent in women, often arises due to abnormalities in the MRN-
checkpoint sensor genes (MRN-CSG), responsible for DNA damage detection and repair …

Homologous recombination (HR) is essential for repair of DNA double-strand breaks (DSBs)
and restart of stalled or collapsed replication forks. Most cancers are characterized by …

Simple Summary Cellular metabolism including lipid metabolism is often altered in cancer
cells. To keep up with the high energetic demand of cancer cells lipid metabolism is …