The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …

Synapse organizing proteins are multifaceted molecules that coordinate the complex
processes of brain development and plasticity at the level of individual synapses. Their …

Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …

Synaptic adhesion molecules (SAMs) shape the structural and functional properties of
synapses and thereby control the information processing power of neural circuits. SAMs are …

Multiple trans-synaptic complexes organize synapse development, yet their roles in the
mature brain and cooperation remain unclear. We analyzed the postsynaptic adhesion …

Astrocytes are the key component of the central nervous system (CNS), serving as pivotal
regulators of neuronal synapse formation and maturation through their ability to dynamically …

Heparan sulfate proteoglycans (HSPGs) are components of the cell surface and
extracellular matrix, which bear long polysaccharides called heparan sulfate (HS) attached …

The perineuronal net (PNN) is a highly latticed extracellular matrix in the central nervous
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan …

Heparan sulfate is a ubiquitous, variably sulfated interactive glycosaminoglycan that
consists of repeating disaccharides of glucuronic acid and glucosamine that are subject to a …

Protein phosphatases are major regulators of signal transduction and they are involved in
key cellular mechanisms such as proliferation, differentiation, and cell survival. Here we …