Heart failure is a global problem with an estimated prevalence of 38 million patients
worldwide, a number that is increasing with the ageing of the population. It is the most …

As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …

Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure,
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM …

Rationale: Doxorubicin is one of the most potent antitumor agents available; however, its
clinical use is restricted because it poses a risk of severe cardiotoxicity. Previous work has …

Background—Adeno-associated virus type 1/sarcoplasmic reticulum Ca2+-ATPase was
assessed in a randomized, double-blind, placebo-controlled, phase 2 study in patients with …

Since techniques for cardiomyocyte isolation were first developed 35years ago, experiments
on single myocytes have yielded great insight into their cellular and sub-cellular physiology …

Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Acute heart failure (HF) and in particular, cardiogenic shock are associated with high
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …

Heart failure is a major cause of death and disability. Impairments in blood circulation that
accompany heart failure can be traced, in part, to alterations in the activity of the …