Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

▪ Abstract Biochemical and genetic approaches have identified the molecular mechanisms
of many genetic reactions, particularly in bacteria. Now a comparably detailed …

There is no doubt that nowadays, biology benefits greatly from mathematics. In particular,
cellular biology is, besides population dynamics, a field where tech niques of mathematical …

In an attempt to provide a rational basis for the optimization of citric acid production by A.
niger, we developed a mathematical model of the metabolism of this filamentous fungus …

This paper concerns oscillations arising in a sequence of biochemical reactions S 0→ S
1↓→ S 2↓→⋯→ S n→ whose end-product inhibits the rate of the first reaction. Except for …

Biochemical systems are among of the oldest application areas of mathematical modeling.
Spanning a time period of over one hundred years, the repertoire of options for structuring a …

The induction of effector genes that encode enzymes is often controlled by the protein
product of a regulator gene that is directly involved in the control of its own expression. This …

Signal transduction by a traditional two‐component system involves a sensor protein that
recognizes a physiological signal, autophosphorylates and transfers its phosphate, and a …

As of yet, steady‐state optimization in biochemical systems has been limited to a few studies
in which networks of fluxes were optimized. These networks of fluxes are represented by …

Enzyme systems within living cells have recently been shown to be highly ordered structures
that violate classic assumptions of the Michaelis-Menten formalism, which originally was …