Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Transfusion Medicine is a dynamically evolving field. Recent high-quality research has
reshaped the paradigms guiding blood transfusion. As increasing evidence supports the …

Extracellular vesicles (EVs) are small, double membrane vesicles derived from leukocytes,
platelets, and cells of other tissues under physiological or pathological conditions …

Red cell transfusion therapy is a common treatment modality in contemporary medical
practice. Although blood collection and administration is safer and more efficient than ever …

Here, we review current data elucidating the role of red blood cell derived microparticles
(RMPs) in normal vascular physiology and disease progression. Microparticles (MPs) are …

Chronic wounds have a large impact on health, affecting∼ 6.5 M people and costing∼ $25
B/year in the US alone. We previously discovered that a genetically modified mouse model …

Background Trauma is the leading cause of death and disability in patients aged 1–46 y.
Severely injured patients experience considerable blood loss and hemorrhagic shock …

Background Red blood cell (RBC) transfusion is a common treatment for anaemia in many
conditions. The safety and efficacy of transfusing RBC units that have been stored for …

Rationale: A major abnormality that characterizes the red cell “storage lesion” is increased
hemolysis and reduced red cell lifespan after infusion. Low levels of intravascular hemolysis …

Cell-free heme (CFH) and hemoglobin (Hb) have emerged as distinct mediators of acute
injury characterized by inflammation and microcirculatory dysfunction in hemolytic …