The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of
magnitude higher than what is currently used in conventional clinical radiotherapy, and has …

Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …

Radiation exposures at ultrahigh dose rates (UHDRs) at several orders of magnitude greater
than in current clinical radiotherapy (RT) have been shown to manifest differential …

In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …

Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy.
Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic …

FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …

A reemergence of research implementing radiation delivery at ultra-high dose rates
(UHDRs) has triggered intense interest in the radiation sciences and has opened a new field …

Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …

Current radiotherapy facilities are standardized to deliver dose rates around 0.1–0.4 Gy/s in
2 Gy daily fractions, designed to deliver total accumulated doses to reach the tolerance limit …